COMPARATIVE ANALYSIS OF ALZHEIMER PROTEINS: STRUCTURE BASED DRUG DESIGNING STUDY
Shivani Patel1, Venkateshwara Rao Joginipally2, Vaishnavi Mallojala1, Shravan Kumar Gunda1*
1Bioinformatics Division, PGRRCDE, Osmania University, Hyderabad – 500007, India
2Department of Zoology, University college of Science, Osmania University, Hyderabad – 500007, India
*Corresponding Author Email id: email@example.com
Neurodegenerative Disease refers to the condition of the brain cells that no longer have the ability to produce neurotransmitters which leads to unnecessary accumulation of proteins in the brain. The accumulation causes problems like memory retention and cognitive functions. Neurodegenerative Diseases are categorized by four major types such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and Amyotropic Lateral Sclerosis. Alzheimer’s sickness (AD) is interminable neurodegenerative turmoil with characterized pathophysiological mechanisms which for the most part target the medial temporal lobe and associative neocortical structures. Pathological hallmarks of AD are neurotic plaques and neurofibrillary tangles. AD causes progressive and restricting declension of cognitive functions like memory, language, reasoning, attention, comprehension, judgment, psychosis, mood disturbance, agitation, and sleep abnormalities. The most common symptom seen in the early onset of the disease is selective short-term memory loss. The disease is invariably progressive, eventually leading to severe cognitive deterioration. The following molecular docking study is a comparative study with already existing Alzheimer’s proteins. The proteins have been compared on the basis of their binding energies against five natural compounds which are selected because they are natural substances obtained from the plants. The results were compared with already existing drugs. The main purpose of using natural compounds is that their side effects are low to none when compared to synthetic compounds and the cost of their drug production will also be low.
Key Words: Alzheimer’s, docking, natural compounds, comparative study.